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Working with IACUC

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The NIH Guidelines for Recombinant DNA and Gene Transfer do not apply to which of the following types of experiments?
Inoculation of recombinant infectious agents into animals
Inoculation of non-recombinant infectious agents into animals
Inoculation of recombinant infectious agents into mice and rats
Laboratory use of recombinant infectious agents for in vitro workThe Animal Welfare Act and Regulations currently apply to which of the following animals?

inoculation of nonrecumbent infectious agents in animals

With the gradual displacement method of carbon dioxide inhalation, what is the optimal percentage of air per minute to be replaced with CO2?
35%-45%
50%-70%
5%-9%
10%-30%

10-30%

Which of the following statements about postoperative care records is TRUE?

For rodents, postoperative records for the group may be kept on cage cards or in laboratory notebooks.

Which of the following statements concerning adjuvants is true?
Alternatives to CFA and IFA adjuvants are more inflammatory, but less expensive.
Less inflammatory alternatives to the use of CFA and IFA adjuvants are available commercially.
PHS Policy prohibits the use of CFA and IFA adjuvants.
The Animal Welfare regulations prohibit the use of CFA and IFA adjuvants.

Less inflammatory alternatives to the use of CFA and IFA adjuvants are available commercially.

According to the Guide, social animals should be housed in pairs or groups. Which of the following is NOT a good justification for housing animals by themselves?
Health problems in an animal
Behavioral reasons such as aggression
Convenience of the research and husbandry staff
Scientific reasons

Convenience of the research and husbandry staff

Which statement does <strong>NOT</strong> apply to experimental surgery on animals?

The need for sterile technique in survival surgeries is at the discretion of the investigator.

Which of the following is true of the primate psychological enrichment program mandated by the Animal Welfare Act and Regulations?
The veterinarian cannot exempt an animal, even for medical reasons.
The IACUC can exempt an animal for scientific reasons, if documented in the approved protocol.
Primates must be enrolled in the program and cannot be exempted.
The animal care staff can exempt an animal for scientific reasons.

The IACUC can exempt an animal for scientific reasons, if documented in the approved protocol.

Prior to IACUC review of the animal use protocol application that describes procedures that are expected to cause more than momentary pain or distress, which of the following is mandated by the Animal Welfare Regulations?

A laboratory animal veterinarian must be consulted.

Prior to beginning any work involving research animals, an investigator must do which of the following?

Obtain IACUC approval for the proposed procedures and then fill out an animal protocol application
Contact the IACUC chairperson to obtain administrative approval for proposed procedures and then complete an animal use protocol application.
Complete an animal use protocol application describing all proposed procedures and obtain IACUC approval.
Complete an animal use protocol application and obtain administrative approval to conduct proposed procedures

Complete an animal use protocol application describing all proposed procedures and obtain IACUC approval.

Which statement about the Occupational Health and Safety Program is false?
Typical services include rabies immunizations, TB testing, and tetanus immunizations.
Each institution must have an Occupational Health and Safety Program for personnel who have significant contact with laboratory animals.
You should enroll in the local Occupational Health and Safety Program before you begin your work with laboratory animals.
You may not decline medical treatments provided as part of the Occupational Health and Safety Program.

You may not decline medical treatments provided as part of the Occupational Health and Safety Program.

The Animal Welfare Act and Regulations currently apply to which of the following animals?
Hamsters
Mice bred for laboratory research
Frogs
Non-vertebrates

mice bred for laboratory research

Which of the following activities would place an animal in category E?
Blood collection from a superficial vessel of a dog
Major surgery in which anesthetics and postoperative analgesics are administered
Lethal dose experiments in which animals are allowed to die without intervention
Observation studies of normal primate behavior

Lethal dose experiments in which animals are allowed to die without intervention

Which of the following statements is true if an investigator wants to use a human clinical area for animal research?
Sanitizing the area after use can be left to the night housekeeping crew as long as they get to the job within 12 hours.
Permission should be obtained from the IACUC and responsible clinical administrators.
Signs announcing the use of animals in a clinical area must be posted on the door of the clinical area for the duration of the procedure.
Signs announcing the use of animals in a clinical area must be posted for 14 days prior to use at high traffic areas throughout the hospital.

permission should be obtained from the IACUC and responsible clinical administrators

Which statement does NOT apply to experimental surgery on animals?
The need for sterile technique in survival surgeries is at the discretion of the investigator.
A goal of sterile technique is to prevent contamination of the surgical site.
Prior planning is very important.
Either general or regional anesthesia is required to prevent pain.

prior planning is very important

Which of the following statements is FALSE concerning the use of ether in the animal facility?
Ether is a compound that remains very stable over time.
Carcasses of animals euthanized by exposure to ether should be placed in an explosion-proof refrigerator or freezer.
Use of ether is prohibited unless the IACUC and/or Biosafety Committee approves it based upon compelling scientific reasons.
The sparks given off by non-explosion-proof refrigerators and freezers can ignite the ether and cause an explosion.

ether is a compound that remains very stable over time

Annually, institutions that use USDA-covered species must report the number of animals used in each pain/distress category to what agency?
United States Department of Agriculture (USDA)
American Association for Laboratory Animal Science (AALAS)
Public Health Service (PHS)
Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC)

United states department of agriculuture (USDA)

The Animal Welfare Act and Regulations currently apply to which of the following animals?

hamsters

Which of the following is <strong>true</strong> of the dog exercise program mandated by the Animal Welfare Act and Regulations?

The IACUC can exempt an animal for scientific reasons, if documented in the approved protocol

Which of the following statements about using a statistical analysis to justify animal numbers is true?
A statistical analysis must be performed for every experimental protocol.
A statistical analysis is not appropriate because the IACUC cannot properly evaluate the results.
A statistical analysis is rarely useful for justifying group sizes because it gives only estimates.
A statistical analysis should be used whenever possible.

a statistical analysis must be performed for every experimental protocol

All of the following would likely reduce the severity of inflammation following CFA use EXCEPT:
using multiple smaller volume injection sites instead of fewer larger volume sites.
maintaining sterility of the antigen solution before it is mixed with the adjuvant.
minimizing the mycobacterial concentration.
using a dilute antigen solution to increase the volume of the CFA/antigen mixture.

maintaining sterility of the antigen solution before it is mixed with the adjuvant

Which task is NOT a function of the IACUC?
Review and approve animal use protocols submitted by investigators
Assist with writing the basic science portions of a grant application
Conduct reviews of the animal care and use program on a semi-annual basis
Inspect the animal facilities on a semi-annual basis

inspect the animal facilities on a semi-annual basis

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