CITI RCR- Using Animals In Research

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Which of the following most clearly illustrates Russell and Burch’s Replacement concept?

The use of computer modeling software instead of using animals in an experiment.

What is the primary purpose of the "3Rs" concept from Russell and Burch?

To decrease the use of animals in research and to minimize pain and distress caused by animal experiments.

Which of the following most accurately describes the process that must occur when working with research animals covered by U.S. federal regulations?

The research team must obtain IACUC approval for the proposed research procedures prior to starting the work.

Which of the following is true regarding the use of animals in research?

The attending veterinarian must be allowed to have access to all research animals at all times.

Which of the following is the general guideline that IACUCs use to evaluate the potential pain of a procedure conducted with animals?

Any procedure that causes pain or distress in human beings may cause pain or distress in other animals.

Which entity is responsible for monitoring institutional compliance with PHS Policy?

The Office of Laboratory Animal Welfare (OLAW)

Which justification would an IACUC most likely accept if a research team plans to withhold pain relief (analgesia) from animals during a project?

Documented evidence that the analgesic agent will interfere with the aims of the project.

Prior to implementing any significant change in the use of animals, what is the most important thing that the research team must do?

Obtain IACUC approval for the change.

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