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Salicylamide is an active ingredient in BC powder, a common OTC remedy. What is its purpose? |
It enhances plasma levels of aspirin in the hopes of decreasing pain levels. |
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Calculate the amount (in grams) of salicylamide and sodium iodide needed for this experiment. |
7.5mmol x 1mol/1000mmol x 137.14g/1mol = 1.028g 8mmol x 1mol/1000mmol x 149.894g/1mol = 1.199g |
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consider the directing effects of the substituents on salicylamide and predict the possible structures of the iodination products. which do you think will be the major product? |
OH is an activating, ortho/para directing substituent. The amide group is deactivating meta directing substituent. Combining both effects, the 3 and 5 positions appear to be most favorable. They overlab with the most negativity. |
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Electron Withdrawing group EWG |
EWG – Withdraws electrons from aromatic ring -Amide in our experiment -Forms + charges on meta positions of ring -Deactivates ring EDG – Adds electrons to the ring -Forms – charges on ortho/para positions -Activates aromatic ring |
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"Insitu" |
Not adding the reactant directly, you are forming it int eh solution to then use in another reaction |
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Is chlorophyl A or B more or less polar and why |
Chlorophyl B in slightly more polar -B has a -CHO and A has a -CH3, the O makes B slightly more polar |
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Are Xanthophylls more or less polar than B-carotene? why? |
B-carotene is a hydrocarbon and therefore is very nonpolar. Xanthophylls are more polar due to the oxygen they contain |
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Would you consider ethyl acetate to be a polar or non-polar solvent? why? |
Moderately polar. The partial (-) charge from the oxygens and the partial (+) charge on the carbon are close enough to cancel each other though resonance. |
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Why do we mark TLC plates with pencil and not with pen |
The ink in the pen could move on the plate with the sample, causing errors in data by adding new marks. |
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Which compounds on the tlc plate are more/less polar? |
Farther up are less polar, than the lower ones |
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What is the purpose of the filter paper in the TLC lab |
Help vaporize solvent system |
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Is silica polar or non polar? |
Polar |
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What are you looking for in a good solvent system? |
Good separation of the compounds |
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50:50 hexane to ethyl acetate |
The nonpolar solvent will move father, faster for the 70:30 and the polar solvent wont move as far, bc 70:30 is more non polar than 50:50. |
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What is TLC used for? |
to test polarity |
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Why is it important not to dilute the initial sample before it has been loaded onto the chromatography column? |
so that the entire sample enters the column in as compact of a band as possible. that eay you have better separation bt samples |
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Which compound would you expect to elute first from the column: unreacted ferrocene, acetylferrocene, or diacytylferrocene? why? |
Unreacted ferrocine b/c it is the least polar |
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Why should you keep water out of the column? |
because it is polar and it will mess up the solvent system |
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Why don’t you want the column to dry out? |
Silia layer will crack and the separation will happen unevenly |
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What are the sand layers for? |
Bottom: to make the silica layer even and level for the separation to occur evenly across the column Top: When the solution splashes into column the sand protects the silica from becoming unlevel. |
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Monomer |
Repeating units that are the building blocks of a polymer |
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Repeating unit |
a group of atoms derived from a monomer and repeats throughout a polymer |
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Condensation polymerization |
When 2 molecules react to form a larger unit while a small molecule, like H2O oir HCl Is eliminated. |
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Cross-Linked polymer |
Polymer formed by polymers linking together though hydrogen bonds |
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Initiator |
a molecule that starts the polymerization |
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Explain the purpose of the hot gravity filtration. Why is it good to use the stemless funnel for this technique? |
The purpose of hot gravity filtration is to remove any insoluble impurities from your sample. It is better to use a stemless funnel because a funnel with a stem is prone to premature recrystallization. |
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What is ligroin? Is it polar or nonpolar? |
Ligroin is a petroleum derivative, it is a volatile hydrocarbon mixture and is nonpolar. |
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