Course A2- introduction to animal care laws, regulations and policies at USC

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Which of the following is a role of AAALAC?

sponsors a voluntary accreditation program for animal care and use programs

Which of the following is false concerning prolonged restraint of animals?

it can be justified simply as a convenience for the research staff.

How do staff members enroll in the medical surveillance program for individuals with animal contact?

fill out the USC on-line health surveillance questionnaire

Which of the following is the most common occupational health problem among personnel who work with laboratory animals?

development of allergies against animals

Which statement concerning non-survival surgery is true?

If an animal undergoes non-survival surgery, the surgical site should be clipped and clean instruments should be used.

Which of the following statements about pithing as a method of euthanasia is false?

it is a simple technique readily performed by untrained students.

What must you do if you are bitten by a research animal at USC?

Report the incident to your supervisor and go to the Workers Compensation clinic

Which statement concerning survival experimental surgery is false?

If the incision site on the skin is disinfected with iodine or chlorhexidine compounds, hair clipping is not necessary.

Which of the following is a reasonable definition of euthanasia?

The act of killing animals by methods that induce rapid unconsciousness and death without pain or distress.

The term IACUC stands for what?

Institutional Animal Care and Use Committee

Which of these statements is true concerning the USDA Animal Welfare Act?

They take precedence over guidelines produced by the Public Health Service, Department of Veterans Affairs, and other government agencies.

According to the Guide, social animals should be housed in pairs or groups whenever possible. Which of the following is not a good justification for housing animals by themselves?

Convenience of the research and husbandry staff.

The NIH Guidelines for Recombinant DNA and Gene Transfer do not apply to which of the following types of experiments?

inoculation of non-recombinant infectious agents into animals

In general, prior to making any significant changes in your use of animals, what must you do?

Obtain IACUC approval.

Which of the following is true concerning exsanguination?

It is a technique that should not be used on conscious animals because loss of large blood volumes produces anxiety.

What are the primary purposes of the "3R’s" concept of Russell and Burch?

Urge scientists to minimize use of animals and to minimize pain and distress caused by animal experiments.

Which parameter would not likely be part of an endpoint policy?

number of animals approved by the IACUC for a particular protocol

Which of the following is not an example of replacement?

The use of a new analgesic that provides better postoperative pain relief

A simple rule to prevent excess blood collection in an animal is to collect no more than what percentage of body weight as blood at one time?


Which of the following statements is true if an investigator wants to use a human clinical area for animal research?

permission should be obtained from the IACUC and responsible clinical administrators.

Which of the following statements about the use of carbon dioxide for euthanasia is false?

It is the preferred method of euthanatizing rabbits, dogs, cats, and primates.

The USDA AWA Regulations require the IACUC to do what two things regarding alternatives?

Ensure that the principal investigator has considered alternatives to painful or distressing procedures, and review a written assurance that alternatives are not available.

Which of the following concerning euthanasia is not true?

Physical methods of euthanasia are most desirable when used on conscious animals.

What does the term zoonoses refer to?

diseases that are transmissible from animals to humans

Which of the following statements about the postoperative period is false?

Postoperative analgesia is not generally needed in rodents.

Blood collections should be spaced far enough apart to prevent which of the following?

shock due to low blood volume, and anemia.

Which reference document contains detailed guidelines for performing euthanasia on a variety of animals?

The Report of the AWMA Guidelines for the Euthanasia of Animals

Cervical dislocation performed by hand can be performed on which of the following animals?

Rats weighing less than 200 grams and rabbits weighing less than 1kg.

The IACUC’s activities to ensure compliance benefit whom?

the institution, the investigator, and the animals

Because they cannot vomit and are not prone to aspiration pneumonia, which of the following animals should not routinely be fasted prior to surgery?

Rodents and rabbits

Which of the following euthanasia agents is recommended for use by itself on a conscious animal?


Which of the following statements concerning the use of carbon dioxide to euthanatize rodents is true?

Compared to adults, neonates are resistant to low oxygen levels, and less susceptible to death by carbon dioxide inhalation.

Which of the following is not considered a physical method of euthanasia?

pentobarbital overdose

Which of the following is a false statement concerning euthanasia of animals?

physical methods are generally preferred over non-physical methods

Which of the following "Guides" is best used as a source of guidelines for animals housed in farm settings?

The "Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching."

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT), the Institute for In Vitro Sciences, and the European Center for Validation of Alternative Methods (ECVAM) are primarily interested in what area?

Performing or sponsoring research into alternatives to animal use for research and testing

What are the two principal animal research regulatory documents used by the Public Health Service?

The PHS Policy on Humane Care and Use of Laboratory Animals and the "Guide for the Care and Use of Laboratory Animals."

If primate chairing is proposed as a method of restraint, which of the following is false?

The primates must be chaired indefinitely if no signs of distress are apparent

Injections of euthanasia agents into the heart may be performed in what group of animals below?

Anesthetized, heavily sedated, or comatose animals only.

Which of the following are not allowed by USDA policy, unless the IACUC approves?

Changes in animal ownership and movement of animals between facilities during the postoperative period.

Which of the following is a false statement concerning cervical dislocation?

because it is a non-physical method, it can be approved by the IACUC without a scientific justification.

Which of the following would not be accepted by an IACUC as the sole justification for performing multiple major survival surgeries?

cost saving

Unlike the USDA AWA regulations, PHS Policy applies to which animals?

All invertebrate species used in research.

Which of the following is not an example of reduction?

The use of a new anesthetic that provides better induction and a shorter recovery period.

The location (room) in which a surgery can be conducted is not dependent on which factor?

Whether the funds are from the VA or from NIH

Why is proper training in euthanasia techniques so important?

Improper technique can cause unnecessary pain and distress in animals.

The three R’s of Russell and Burch stand for what?

Replacement, reduction, and refinement

Prior to beginning any work involving research animals, an investigator must do which of the following?

Fill out animal protocol forms describing all proposed procedures, and receive IACUC approval.

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