What is the body’s 2nd great controlling system? |
The Endocrine System |
What 2 systems act to maintain homeostasis? |
Nervous & Endocrine |
T/F Hormones wash over all cells but only affects target cells. |
True |
When hormones are being classified chemically, there are two groups. What are they? |
Amino Acid Based Hormones & Steroid Based Hormones |
What are the 6 major endocrine glands? |
1. Pineal gland 2. Pituitary gland 3. Thyroid gland 4. Parathyroid glands 5. Thymus gland 6. Adrenal gland |
What is the second great control system of the body that interacts with the nervous system to coordinate and integrate the activity of body cells? |
The Endocrine System |
T/F: The control and speed of the endocrine system is similar to that of the nervous system. |
False |
The endocrine system influences metabolic activity by means of what? |
Hormones |
The word "hormone" means… |
to excite |
What are hormones? |
Chemical messengers released into the blood to be transported throughout the body |
Binding of a hormone to cellular receptors initiates responses that typically occur after a lag period of seconds or even days. Although this makes the system slower than the nervous system, what is the upside to this? |
Once initiated, the response tends to be much more prolonged than those induced by the nervous system |
T/F: Hormonal targets ultimately include most cells of the body, and hormones have widespread and diverse effects. |
True |
The major processes controlled and integrated by hormones are… (5) |
1. reproduction 2. growth and development 3. maintenance of electrolyte, water, and nutrient balance of the blood 4. regulation of cellular metabolism and energy balance 5. mobilization of body defenses |
What is the term defined as the scientific study of hormones and the endocrine organs |
Endocrinology |
T/F: compared with other organs of the body, those of the endocrine system are small and unimpressive. |
True |
The endocrine system differs from other bodily systems in terms of arrangement. Explain. |
They are not grouped together but rather widely spread throughout the body. |
What is the name for the glands which produce nonhormonal substances, such as sweat and saliva, & have ducts that carry these substances to a membrane surface. |
Exocrine glands |
What is the name for the glands which produce hormones and lack ducts. |
Endocrine glands |
T/F: Endocrine glands typically have a rich vascular and lymphatic drainage that receives their hormones. |
True |
Most of the hormone-producing cells in the endocrine glands are arranged in _____ and _____ networks– a situation that maximizes contact between the cells and the capillaries surrounding them. |
Most of the hormone-producing cells in the endocrine glands are arranged in CORDS and BRANCHING networks– a situation that maximizes contact between the cells and the capillaries surrounding them. |
Define a neuroendocrine organ. |
organs which have neural functions as well as producing and releasing hormones (ex. hypothalamus) |
T/F: Very few organs contain scattered endocrine cels or small clusters of endocrine cells. |
False; many organs |
T/F: Hormone-producing cells are found in the walls of the small intestine, stomach, kidneys, and heart. |
True |
Are autocrines and paracrines part of the endocrine system? Why or why not? |
No |
Are hormones long or short-distanced chemical signals that travel in blood or lymph throughout the body? |
Long-distanced |
Chemicals that exert their effects on the same cells that secrete them are called what? |
Autocrines |
Chemicals that exert their effects locally but affect cell types other than those releasing the chemical are called what? |
Paracrines |
Certain tumor cells synthesize hormones __________ to those made in normal endocrine glands. |
identical |
What term can be defined as "chemical substances, secreted by cells into the extracellular fluids that regulate the metabolic function of other cells in the body"? |
Hormones |
Most hormones are ___________ based. (steroid or amino acid) |
amino acid |
Do amino based hormones vary in molecular size? |
Yes. |
Steroids are synthesized from ____________. |
cholesterol |
Of the hormones produced by major endocrine organs, only 2 hormones are steroids.. which ones are they? |
Gonadal and adrenocortical hormones |
T/F: All circulating hormones in the body are organic molecules. |
True |
Insulin, PTH, and epinephrine are the top three ________ based hormones in the human body. |
amino acid based hormones |
Leukotrienes and prostaglandins are considered __________. |
Eicosanoids |
Define eicosanoids |
biologically active lipids (made from arachidonic acid) which are released by nearly all cell membranes. |
These are made from arachidonic acid. |
Eicosanoids |
_______ are signaling chemicals that mediate inflammation and some allergic reactions. |
leukotrienes |
_________ are signaling chemicals that have multiple targets and effects, ranging from blood pressure and increasing the expulsive uterine contractions of birth to enhancing blood clotting, pain, and inflammation. |
prostaglandins |
Eicosanoids generally act as paracrines and autocrines and do not fit the definition of a true hormone. Why? |
Because they are highly localized meaning they only effect nearby cells (true hormones influence distant targets) |
If a hormone is a protein or peptide it is usually _______ based. |
amino acid |
If a hormone is derived from cholesterol, it can be assumed that the hormone is a _________. |
steroid |
T/F: Amino acid based hormones are pure amino acids. |
False; they are modified amino acids |
Most of these hormones are water soluble. |
Amino acid based |
Most of these hormones are lipid soluble. |
Steroid base hormones |
If a hormone is lipid soluble, then what does it need to do? |
it needs a protein carrier to travel through plasma |
Amino acid hormones are synthesized on the…. (hint: organelle) |
rough ER |
Steroid based hormones are synthesized on the…. (hint: organelle) |
smooth ER |
Most _________ based hormones work through a second messenger system (cAMP). |
amino acid |
Which type of hormone cannot be taken orally in most cases? |
Amino acid based |
Do steroid based hormones or amino acid based hormones bind to membrane receptors? |
Amino acid based hormones |
Do steroid based hormones or amino acid based hormones bind to intracellular receptors? |
Steroid based hormones |
_______ based hormones stimulate gene activation and protein synthesis. |
Steroid |
These hormones can be taken orally. |
Steroid based hormones |
Thyroid hormones act like ________ hormones but are not. |
Thyroid hormones act like STEROID BASED hormones but are not. |
Being _____ soluble, these hormones can diffuse directly into the cell and direct gene activation. |
lipid soluble (steroid based hormones) |
Cells that have receptors for specific hormones are called what? |
Target Cells |
Hormones bring about their characteristic effects on target cells by _______ cell activity. |
altering |
T/F: Hormones increase or decrease the rates of normal cellular processes. |
True |
T/F: Thyroid hormone is water soluble. |
False; although it is an amino acid based hormone, it acts like a steroid in many ways. One being that it is not water soluble |
Water soluble hormones act on receptors in the… |
plasma membrane. |
With the exception of thyroid hormone, all amino acid-based hormones exert their signaling effects through intracellular ________ generated when a hormone binds to a receptor on the plasma membrane. |
With the exception of thyroid hormone, all amino acid-based hormones exert their signaling effects through intracellular SECOND MESSENGER generated when a hormone binds to a receptor on the plasma membrane. |
On of the second messengers, _______, is used by neurotransmitters and olfactory receptors. |
cyclic AMP (aka cAMP) |
5 Steps to the cAMP signaling mechanism. |
1. Hormone acts as first messenger by binding to plasma membrane receptor protein forming a R-H complex 2. R-H complex stimulates formation of cAMP (2nd messenger) 3. cAMP activates specific protein kinases in the cell 4. protein kinases phosphorylate enzymes and other proteins already in the cell 5. step 4 then activates or inactivates specific enzymes to open or close membrane channels |
4 actions made by steroid hormones… |
1. lipid soluble hormones diffuse though the lipid bilayer and bind to intracellular receptors 2. R-H complex binds to and activates a specific gene (direct gene expression occurs) 3. protein synthesis is stimulated 4. the new protein may be an enzyme, secretion, a membrane protein, etc. |
T/F: cAMP is slow. |
False; cAMP is very FAST |
All major endocrine glands are linked ONLY by the __________. |
blood |
Melatonin is produced by what gland? |
Pineal gland |
What gland regulates amounts of calcium? |
Parathyroid gland |
What is the hypophysis? |
referring to the hypothalamus and pituitary gland as one structure |
GH, TSH, FSH, LH, ACTH, prolactin are produced where? |
anterior pituitary |
Posterior lobe of the pituitary is made up of…. |
nervous tissue. |
also known as "The Master Gland" |
Hypothalamus |
T/F: Hypothalamus releases & inhibits hormones |
True |
When referring to the hypophyseal portal system of the pituitary, are we dealing with the anterior or posterior pituitary? |
Anterior pituitary |
The anterior pituitary produces ___(#) hormones, ___(#) of which are tropic hormones. |
The anterior pituitary produces 6 hormones, 4 of which are tropic hormones. |
75% of glandular weight is found in the anterior or posterior pituitary? |
anterior pituitary |
When referring to the hypothalamic-hypophyseal tract of the pituitary, are we dealing with the anterior or posterior pituitary? |
Posterior |
In terms of hormones, the posterior pituitary does what? |
STORES 2 hormones that are produced by hypothalamus (ADH & oxytocin) |
What two hormones are stored in the posterior pituitary? |
ADH & oxytocin |
2 main actions of hGH |
-release of insulin-like growth factors from liver -increase blood glucose levels (anti-insulin effects) |
Are proteins able to be taken orally? |
No |
The term "tropic" means what? |
to stimulate another gland |
What’s the term used to describe the situation when one hormone cannot exert its full effects without another hormone being present. |
Permissiveness |
________ of hormones occurs in situations where more than one hormone produces the same effects at the target cell and their combined effects are amplified. |
Synergism |
When one hormone opposes the action of another hormone, the interaction is called _________. |
antagonism |
T/F: The synthesis and release of most hormones are regulated by some type of positive feedback. |
False; negative feedback |
T/F: Thyroid Stimulating Hormone acts like a steroid based hormone although it is not one. |
False; do not confused thyroid hormone with thyroid STIMULATING hormone |
________ stimulates iodide uptake and production of T3 and T4 |
TSH (thyroid stimulating hormone) |
T3 & T4 refers to the __________ hormones. |
Thyroid hormones (which do act like steroids) |
_____ stimulates release of ACTH. |
CRH (corticotropin releasing hormone) |
ACTH (adrenocorticotropic hormone) stimulates release of _______ from the adrenal cortex to help fight _________. |
ACTH (adrenocorticotropic hormone) stimulates release of CORTISOL from the adrenal cortex to help fight EVERYDAY STRESSORS. |
What hormone is released when you fall under stress (all stress-both physical & emotional)? |
ACTH (adrenocorticotropic hormone) |
What are the 2 main gonadotropins? |
FSH & LH |
Gonadotropins are under the control of _____ from the _________. |
Gonadotropins are under the control of GnRH from the HYPOTHALAMUS. |
____ & ____ are both hormones whom regulate the functions of ovaries and testes. |
FSH & LH |
T/F: Prolactin is tropic. |
No! |
Why is prolactin not considered tropic? |
Because mammary glands are exocrine glands through milk production |
In females, _________ stimulates development of mammary glands and milk production. |
Prolactin (PRL) |
Prolactin is usually inhibited by ______. |
PIH (dopamine) |
T/F: PRH levels drop toward end of pregnancy. |
False; they rise toward the end of pregnancy |
Posterior pituitary stores two hormones. What are they? |
ADH & Oxytocin |
ADH stands for |
antidiuretic hormone |
When is ADH released? |
When blood volume is low When osmolarity is high When there is a decrease of oxygen content in blood |
When _____ is released, it stimulates the insertion of aquaporins into CD cells |
ADH |
T/F: Vasopressin and ADH are synonymous. |
True |
_________ is release when pressure increases on cervix or when baby suckles on nipples. |
Oxytocin |
_______ stimulates uterine contractions and milk let-down reflex. |
Oxytocin |
The milk let-down refers to milk _______. |
ejection |
Is it ADH or oxytocin has been theorized to play a role in sexual arousal and nurturing? |
Oxytocin |
T/F: Oxytocin stimulates smooth muscle to contract. |
True |
FSH stands for.. |
follicle-stimulating hormone |
What hormone stimulates sperm production? |
FSH |
LH stands for.. |
luteinizing hormone |
____ triggers ovulation and stimulates ovarian production of estrogen and progesterone; promotes testosterone production in males. |
LH |
____ stimulates kidney tubule cells to reabsorb water. |
ADH aka vasopressin |
The 3 major types of stimuli that trigger endocrine glands to manufacture and release their hormones are… |
1. humoral stimuli (direct response to blood level changes) 2. neural stimuli 3. hormonal stimuli |
The funnel-shaped stalk that connects the pituitary gland to the hypothalamus superiorly is the ____________. |
infundibulum |
The posterior lobe plus the infundibulum of the pituitary gland makes up the region called the ___________. |
neurohypophysis |
T/F: The neurohypophysis indicates the posterior lobe alone. |
False (posterior lobe + infundibulum) |
Adenohypophysis is another name for.. |
the anterior pituitary |
The ________ is composed of glandular tissue; it manufactures and releases a number of hormones. |
anterior pituitary (aka adenohypophysis) |
The anterior lobe is made up of ______ tissue and the posterior lobe is made up of ______ tissue. |
epithelial; nervous |
The glandular anterior lobe originates from a superior out-pocketing of the oral mucosa called _______. |
Rathke’s pouch |
T/F: There is no direct neural connection between the anterior lobe and hypothalamus, but there is a vascular connection. |
True |
The primary and secondary capillary plexuses and the intervening hypophyseal portal veins make up the _______. |
hypophyseal portal system |
An unusual arrangement of blood vessels in which a capillary bed feeds into veins, which in turn feed into another capillary bed, defines a _________. |
portal system |
A tropin is… |
a tropic hormone. |
_______ are hormones that regulate the secretory action of other endocrine glands. |
Tropins (or tropic hormones) |
All anterior pituitary hormones except for _________ affect their cells via a cyclic AMP second messenger system. |
growth hormone |
Growth hormone is produced by cells called ___________ of the anterior lobe and has both growth-promoting and metabolic actions. |
somatotrophs |
GH’s major targets are the _____ and the ______. |
bones & skeletal muscles |
Stimulation of the _____ leads to long bone growth, and stimulation of ______ promotes increased muscle mass. |
Stimulation of the EPIPHYSEAL PLATE leads to long bone growth, and stimulation of SKELETAL MUSCLES promotes increased muscle mass. |
T/F: GH promotes protein synthesis, and it encourages the use of fats for fuel, thus conserving glucose. |
True |
Secretion of GH is regulated chiefly by 2 hypothalamic hormones with antagonistic effects. What are they? |
GHRH (Growth hormone-releasing hormone) GHIH (Growth hormone-inhibiting hormone, aka somatostatin) |
Somatostatin is synonymous for _____. |
Growth hormone-inhibiting hormone (GHIH) |
Typically, GH secretion has a daily cycle, with the highest levels during what phase of the day? |
during evening sleep |
T/F: The total amount of GH secreted daily from adolescence on increases with age. |
False; decreases with age. |
T/F: GHIH is produced in various locations in the gut where it inhibits the release of virtually all gastrointestinal and pancreatic secretions–both endocrine and exocrine. |
True |
Hypersecretion of GH in children results in _______. |
gigantism |
Hypersecretion of GH in adults results in _______. |
acromegaly |
What cells produce calcitonin? |
parafollicular cells |
______ is a glycoprotein called thyroglobulin that has iodine attached to the tyrosine amino acid. |
Colloid (as in colloid filled follicle cells of the thyroid gland) |
___ & ___ make up the thyroid hormones. |
T3 & T4 |
BMR stands for.. |
basal metabolic rate |
Are thyroid hormones polar are nonpolar? |
nonpolar |
Thyroid hormones are ______ soluble. |
lipid |
T/F: Thyroid hormones use the 2nd messenger system. |
False; Thyroid hormones use direct gene activation |
What is the largest pure endocrine gland in the human body? |
The thyroid gland |
The thyroid gland is composed of _______ that produce the glycoprotein, __________. |
The thyroid gland is composed of FOLLICLES that produce the glycoprotein, THYROGLOBULIN. |
Thyroglobulin + Iodine = |
Colloid |
_______ is the precursor of thyroid hormones. |
Colloid |
Calcitonin is released when levels of Ca2+ are ______. |
high |
T/F: Calcitonin brings calcium levels back up. |
False; Calcitonin brings calcium levels back down. |
T/F: Thyroid hormones effect the skeleton & nervous system. |
True |
________ hormones regulate BMR. |
Thyroid |
What are the four main actions of thyroid hormones? |
-they increase lipolysis (breakdown of fat) -they increase protein synthesis (ATP production) -Important for growth & development of the skeleton and NS -Enhances actions of the sympathetic NS. |
The breakdown of fat is termed as ________. |
lipolysis |
Cretinism, myxedema, & Hashimoto’s are all examples of ____________. |
hypothyroidism |
Graves’ disease is an example of ___________. |
hyperthyroidism |
T/F: When suffering from hyperthyroidism or hypothyroidism, one can medication orally. |
True |
________ in adults has symptoms such as weight gain, extreme fatigue, hair loss, cold intolerance (meaning they are always cold), and dry skin. |
Hypothyroidism |
When an adult suffers from hypothyroidism, his/her BMR will have _______. |
dropped |
________ in adults has symptoms such as anxiety, weight loss, lack of sleep, wet/oily skin, and heat intolerance (meaning they are always hot). |
Hyperthyroidism |
When an adult suffers from hyperthyroidism, his/her BMR will have _____. |
increased |
T/F: In graves’ disease, the person will have autoantibodies which mimic TSH |
True |
What is the exophthalmos of Graves’? |
bulging of the eyes from swelling of tissue which sits behind the eye, usually from a smoker. |
Chief cells which release PTH make up the ________. |
Parathyroid glands |
How many parathyroid glands does the average person have? |
4 but can have up to 8 |
When Ca2+ levels decrease, what glands secrete an antagonist to calcitonin called PTH? |
Parathyroid glands |
When Ca2+ levels go up, what happens? |
parafollicular cells produce calcitonin. Calcitonin triggers the kidneys to secrete more Ca2+ into the urine. This inhibits osteoclasts, and intestines will decrease absorption. |
A patient is losing weight rapidly, sweating profusely, and is always anxious. The patient may be suffering from _________. |
hyperthyroidism |
___________ are produced by the cortex of the adrenal glands. |
corticosteroids |
_________ produces epinephrine and norepinephrine, which are amino acids. |
The medulla (sitting inside of the cortex of the adrenal gland) |
The 3 zones making up the cortex of the adrenal glands are… |
1. Outer (aldosterone) 2. Middle (cortisol) 3. Inner (testosterone) |
All adrenal hormones help us cope with _______. |
stresses (all; physical, emotional, minor, major, etc.) |
Adrenal glands are made up of two different parts. What are they? |
The medulla (inner) & the cortex (outer) |
Modified ganglionic neurons of sympathetic NS make up the ________. |
Medulla of the adrenal gland |
T/F: The hormones from the medulla are NOT essential to life, but help resist stress. |
True |
Glandular epithelial cells that secrete corticosteroids that are essential to life make up the __________. |
cortex of the adrenal gland |
Do all corticosteroids derive from cholesterol? |
Yes |
________ stimulates Na+ reabsorption and K+ secretion in the kidneys. |
Mineralcorticoids (Aldosterone) |
Mineralcorticoids (Aldosterone) are released when blood [Na2+] is ________ or [K+] is ________. |
Mineralcorticoids (Aldosterone) is released when blood [Na2+] is LOW or [K+] is HIGH. |
When blood pressure and blood volume are low, _______ is released. |
renin |
The medulla produces what catecholamines? |
Epinephrine and norepinephrine |
What do glucocorticoids do? |
They help resist longer lasting stressors, such as keeping blood nutrient levels and blood pressure up |
Vasoconstriction, gluconeogenesis, lipolysis and fatty acid oxidation, and protein catabolism are all processes done by _______. |
glucocorticoids |
Androgens are synonymous for _______. |
gonadocorticoids |
_________ contribute to the onset of puberty, appearance of secondary sex characteristics, and sex drive in females. |
Gonadocorticoids (androgens) |
_________ can be converted into estrogens after menopause. |
Androgens (gonadocorticoids) |
Hypersecretion of androgens (gonadocorticoids) will result in ________. |
female masculinization |
__________ are secreted by the outermost region of the adrenal cortex. |
mineralcorticoids |
The principal mineralcorticoid is ___________, which acts to conserve sodium ions and water in the body and secrete potassium. |
Aldosterone |
_________ are secreted by the middle region of the adrenal cortex. |
Glucocorticoids |
The principal glucocorticoid is ___________, which helps combat stressors by increasing fat & protein metabolism and increasing blood glucose levels. |
cortisol |
___________ are the sex hormones. |
Gonadocorticoids |
___________ is the adrenal hormone responsible for maintaining appropriate blood sodium and potassium levels. |
Aldosterone |
During times of stress, elevated levels of _____ often occur, which explains why we get a cold during final exam time. |
cortisol |
Along with the sympathetic nervous system, the __________ is the other primary mediator of acute stress. |
adrenal medulla |
T/F: The pancreas is strictly an endocrine gland. |
False; it is both endocrine and exocrine |
_______ and ________ help maintain blood glucose levels. |
insulin & glucagon |
What are the two main hormones produced by the pancreas? |
insulin & glucagon |
_______ is released from beta cells during fed (absorptive) phase. |
Insulin |
Insulin enhances: |
-glucose & amino acid transport into cells -glucose oxidation -glycogenesis -lipogenesis -protein synthesis |
_______ is released from alpha cells during postabsorptive (fasting) phase. |
Glucagon |
Glucagon’s major target is the ______. |
Liver |
Glucagon enhances: |
-glycogenolysis -lipolysis -gluconeogenesis -protein catabolism |
Inability to produce or respond to insulin results in ______. |
diabetes mellitus |
3 cardinal signs of diabetes mellitus. |
-polyuria -polydipsia -polyphagia |
Cushing’s disease |
accumulation of fluids and fats in face,neck, and upper back: caused by overproduction of adrenocortical steroids |
In diabetes mellitus, there is decreased glucose available for cellular respiration. What happens because of this? |
-neurons starve resulting in neuropathy & coma -increased fatty acid oxidation leads to cardiovascular disorders -weight loss -ketogenesis which can lead to coma |
T/F: Type I Diabetes Melitus is insulin dependent. |
True |
T/F: Light inhibits release of melatonin. |
True |
The secretion of ________ helps regulate our circadian rhythms. |
melatonin |
Circadian rhythm |
the biological clock; regular bodily rhythms that occur on a 24-hour cycle |
Alpha cells produce __________. |
glucagon |
Beta cells produce ___________. |
insulin |
Although an endocrine structure, the _______ is essentially a modified sympathetic ganglion. |
adrenal medulla |
The _________ produces what’s known as atrial natriuretic peptide (ANP) hormones. |
heart |
ANP reduces 3 things. What are they? |
blood pressure blood volume blood sodium concentration |
What is the antagonist to aldosterone? |
ANP (atrial natriuretic peptide) |
The ___________ produces the hormones, secretin and CCK. |
gastrointestinal tract |
________ & ________ stimulate secretion of bile and pancreatic juice into duodenum while inhibiting gastric activities. |
Secretin & CCK |
What organ produces the hormone erythropoietin (EPO)? |
The kidneys |
What hormone is known for stimulating RBC production? |
erythropoietin |
What are the three main functions of the blood? |
Transport Protection Regulation |
What is normal range for blood pH? |
7.35 – 7.45 |
Blood takes up approximately ___% of total body weight. |
8 |
What are the components of whole blood? |
RBCs (~45%) WBCs Platelets Plasma (~55%) |
What component of whole blood takes up over half of the space? |
Plasma |
What is plasma made up of? |
90% water, 8% proteins, rest is waste |
What are the three proteins found in blood plasma? |
albumins (60%) globulins (36%) clotting factors make up the rest |
T/F: Erythrocytes have concave discs with few organelles. |
False; erythrocytes have biconcave discs with no organelles |
_______ make up more than 99% of the formed elements. |
erythrocytes |
How long does erythropoiesis take? |
~15 days |
What is the name for the process of making red blood cells? |
Erythropoiesis |
What affects the rate or stimulates of erythropoiesis? |
the oxygen carrying capacity of the blood |
EPO stands for |
erythropoiesis |
______ produce(s) hemoglobin. |
Erythroblasts |
The 3 phases of erythropoiesis are… |
Phase 1 – ribosome synthesis Phase 2 – hemoglobin accumulation Phase 3 – ejection of nucleus |
RBCs are synonymous with |
erythrocytes |
______ stimulates kidneys to release EPO. |
Hypoxia |
____ is an intrinsic factor produced by stomach; allows for absorption in small intestine. |
B12 |
How long do new RBCs function in the blood stream? |
~120 |
Along with erythropoietin, what are the necessary raw materials needed for erythropoiesis? |
Amino acids (for globin synthesis) Iron (Fe) B12 (comes from animals) Folic acids (comes from leafy materials) |
Most macrophages for RBCs are in these two organs. |
liver & spleen |
Aged RBCs are engulfed by WBCs called _____. |
macrophages |
What makes feces brown? |
Bilirubin |
_______ is an erythrocyte disorder due to having an oxygen capacity too ow to keep up with all of the body’s responsibilities. |
Anemia |
Most common form of anemia in the U.S. is ________. |
Iron-deficiency anemia |
A person with iron-deficient anemia needs what mg/day? |
15 mg/day |
If a patient is suffering from anemia of his/her microcytes, it is considered ______ anemia. |
iron-deficiency anemia |
T/F: Women who are iron deficient tend to have lighter menstrual cycles. |
False; they tend to have heavy menstrual cycles |
When someone suffering from anemia has a want to chew on nonfoods such as ice, what is that person experiencing? |
Pagophagia |
______ is a genetic disorder that affects the globin, forming odd-shaped hemoglobin. |
Thalassemia |
T/F: A number of different genes could be affected in thalassemia. |
True |
_____ is a form of anemia that affects the confirmation of hemoglobin through beta chain substitution. |
Sickle cell |
When red blood cells become very thick and paced, they are hard to transport. This is what happens during ___________, and is also the reason for altitude sickness. |
polycythemia |
______ are capable of diapedesis, amoeboid action, and chemotaxis. |
WBCs |
During _______, WBCs are capable of squeezing through capillary endothelial cells into tissue spaces. |
Diapedesis |
RBC & platelets are NOT whole cells because they lack a _________ and other _________. |
RBC & platelets are NOT whole cells because they lack a NUCLEUS and other ORGANELLES. |
_______ happens when WBCs are moving toward secreted chemicals. |
Chemotaxis |
T/F: WBCs cannot leave blood & still be able to function. |
False; WBC can leave, but RBC cannot! |
Can RBC leave the blood? |
No, or they will die. |
The ____________ are granulocytes that increase in # due to acute bacterial infection. |
Neutrophil |
The _________ are granulocytes which increase in # due to parasitic infection & dampening allergic reactions. |
Eosinophils |
T/F: Eosinophils are strong phagocytes. |
False; They are very weak which gives reason to why it dampens allergic reactions |
___________ are granulocytes who have granules containing histamine and heparin. |
Basophils |
_______ initiates the inflammatory response. |
Histamine |
What is the acronym describing the order of leukocytes in the blood. |
Never Let Monkeys Eat Bananas (neutrophils (50-70%), lymphocytes, monocytes, eosinophils, and basophils.) |
Hb (hemoglobin) is primarily split into _______ and _______. |
Globin and Heme |
Once hemoglobin has split into globin & heme, the globin is made up of _________ which are recycled & reused in the body. |
Amino Acids |
Once hemoglobin has split into globin & heme, the heme is split into two parts. What are they? |
The iron part & the noniron part |
T/F: Once hemoglobin has been split into globin and heme, the heme excretes its’ iron part. |
False; iron part is reused… the noniron part forms bilirubin & liver excretes it into bile. |
_______ have granules that contain hydrolytic enzymes, lysozymes, and defensins; They are also termed "the bacteria slayers" |
Neutrophils |
_______ have spear-like things that poke holes in foreign bacteria, making bacteria leak its’ juices thus killing them. |
Defensins |
_______ combat parasitic worm infections by increasing their numbers during allergic reactions & parasitic worm infections. |
Eosinophils |
Which leukocyte is known for taking up eosin from Wright’s stain? |
Eosinophils |
_______ lessen the severity of allergies by phagocytizing immune complexes. |
Eosinophils |
_________ mediate an inflammatory response. |
Basophils |
Granules of this leukocyte contain histamine and heparin to mediate an inflammatory response and attract other WBCs. |
Basophils |
B cells & T cells are subtypes for what leukocyte? |
Lymphocytes |
__________ develop from lymphoid stem cells, playing an important role in immunity. |
Lymphocytes |
T/F: Lymphocytes are capable of mitosis and can live for years. |
True |
What are the subtypes of lymphocytes? |
T cells & B cells |
T cells of lymphocytes are broken down further into two types. What are they? |
CD4 (T helper cells) CD8 (T killer cells) |
Of the 2 subtypes of lymphocytes, which one is known for targeting specific antigens. |
T cells |
______ is a subtype of lymphocytes that divides into memory cells & plasma cells which create antibodies |
B cells |
This leukocyte is the largest of them all. |
Monocytes |
Are monocytes specific or nonspecific? |
Nonspecific (eats anything foreign) |
_______ leave the circulation, enter tissue, and differentiate into fixed & wandering macrophages; increase in numbers during chronic infection |
Monocytes |
What are the two types of macrophages which monocytes differentiate into? |
Fixed macrophages & Wandering macrophages |
Kupffer cells in the liver show examples of these _______. |
Fixed macrophages of monocytes |
T/F: Monocytes go out to areas of infection. |
True |
__________ is the process referring to the formation of WBCs. |
Leukopoiesis |
Leukopoiesis is stimulated by __________. |
Cytokines |
What is considered the parent cell of leukopoiesis? |
Hemeocytoblast |
_________ are merely fragments of cells. |
Platelets |
Platelets are formed specifically by what cell? |
Megakaryocyte |
Thrombocytes are synonymous with…. |
Platelets |
Mitosis without cytokinesis forms a ____________. |
Megakaryocyte |
T/F: There are no organelles involved in hemostasis. |
True |
The stoppage of bleeding refers to what process? |
Hemostasis |
What are the 3 main steps in hemostasis? |
1. Vascular spasm (causing vasoconstriction) 2. Platelet plug (putting gum on a cracked pipe) 3. Coagulation (clot formation) |
T/F: During coagulation, the series of clotting factors are proteins. |
True |
_____ forms a mesh that traps RBCs and platelets, forming the clot. |
Fibrin |
To ensure stability of the platelet plug, a ______ forms. |
clot |
What are the 3 stages of coagulation? |
1. Formation of prothrombinase (intrinsic & extrinisic pathways) 2. Formation of Thrombin (from prothrombin) 3. Formation of Fibrin (from fibrinogen) |
T/F: Intrinsic pathways working by themselves is normal. |
False; only normal when extrinsic is working too |
Which pathway of coagulation has no external injury at all. |
Intrinsic pathway |
During injury when your cut, what pathway of coagulation is used? |
Extrinsic pathway |
XII -> XI -> IX -> VIII |
Intrinsic pathway |
III + VII |
Extrinsic pathway |
Tissue factor represents the ______ pathway. |
extrinsic |
4 factors affecting clot formation |
-Vitamin K -Calcium -Tissue Factor -Factor IX |
_________ is required by the liver to produce several clotting factors. |
Vitamin K |
_________ is a necessary cofactor in many of the reactions during coagulation. |
Calcium |
_______ initiates the extrinsic pathway and speeds up clot formation from minutes to seconds. |
The tissue factor |
Factor IX is only involved in the ________ pathway. |
intrinsic |
The process of clot removal is known as _______. |
Fibrinolysis |
During fibrinolysis, what happens? |
The blood clot induces the secretion of TPA (tissue plasminogen activator). TPA secretes plasminogen which converts to plasmin. Plasmin dissolves blood clot by breaking down fibrin. |
Plasmin dissolves blood clot in fibrinolysis by breaking down _________. |
fibrin |
__________ are substances that inhibit the process of clotting. |
Anticoagulants |
What are the two main substances that inhibit the process of clotting? |
Heparin & Warfarin (aka coumadin) |
________ is released from mass cells and basophils and blocks thrombin. |
Heparin |
T/F: Heparin cannot be given by injection. |
False; heparin can be given by injection |
_________ blocks thrombin while ________ inhibits the activity of vitamin K. |
HEPARIN blocks thrombin while WARFARIN inhibits the activity of vitamin K. |
What is taken orally for long-term control of blood clotting? |
Coumadin (aka warfarin) |
Aspirin ______ platelet activation and platelet plug formation. |
prevents |
T/F: Sugar groups always go out of the cell on to the surface. |
True |
Someone who has Type A blood has what antibodies? |
anti B antibodies |
Someone who has Type AB blood has what antibodies? |
No antibodies |
Someone who has Type O blood has what antibodies? |
Both A & B antibodies |
____________ occur mismatched blood is mixed. |
Transfusion reactions |
During transfusion reactions, the _____’s cells are attacked by the _____’s antibodies. |
During transfusion reactions, the DONOR’s cells are attacked by the RECIPIENT’s antibodies. |
During transfusion reactions, the donor’s cells are attacked by the recipient’s antibodies causing _______ and ________. |
Agglutination & Hemolysis |
During agglutination & hemolysis, what 3 things are happening? |
1. decreased oxygen-carrying capacity 2. blockage of small blood vessels 3. free Hb (hemoglobin) precipitates out in kidney tubules causing renal failure |
During agglutination & hemolysis, free Hb precipitates out in kidney tubules causing…. |
renal failure. |
There are at least 45 different Rh antigens, but which one is the most important? |
The D antigen |
When there is a presence of the D antigen, then the person will be… |
Rh+ |
When there are no Rh antigens on cell membranes, then the Rh is… |
negative. |
When Rh antigens are present on cell membranes, the Rh is… |
positive. |
T/F: During pregnancy, there will be exchange of blood types. |
False |
_________ is the hemolytic disease of newborns across 2 pregnancies |
Erythroblastosis Fetalis |
Could a man with Type B blood and a woman with TYPE AB blood produce and O child? Why or why not? |
No, O is recessive |
Phagocytes that target acute bacterial infections are ______. |
neutrophils |
Macrophages are also known as __________. |
monocytes |
T killer cells that go directly after antigens. |
Lymphocytes |
Blood type A genotype(s). |
AA or AO which contain B antibodies |
Blood type AB genotype(s). |
AB, no antibodies |
Blood type O genotype(s). |
OO, which contains both A & B antibodies. |
Universal blood type: |
Blood type AB |
Destruction of RBCs: The iron & amino acids are __________ and the remainder is converted to _________. |
Destruction of RBCs: The iron & amino acids are RECYCLED (reused) and the remainder is converted to BILIRUBIN. |
________ the major hyposecretory disorder of the adrenal cortex. |
Addison’s disease |
A&P 2 Exam 1
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